https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54979 Wed 27 Mar 2024 09:31:09 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36968 2 [IQR 7–21]) compared to benign thyroid (6 nerves/cm² [IQR: 3–10]) (p = 0.001). In contrast, no increase in nerve density was observed in FTC. In multivariate analysis, nerve density correlated positively with extrathyroidal invasion (p < 0.001), and inversely with tumour size (p < 0.001). The majority of nerves were adrenergic, although cholinergic and peptidergic innervation was detected. Perineural invasion was present in 35% of PTC, and was independently associated with extrathyroidal invasion (p = 0.008). This is the first report of infiltration of nerves into the tumour microenvironment of thyroid cancer and its association with tumour aggressiveness. The role of nerves in thyroid cancer pathogenesis should be further investigated.]]> Wed 24 May 2023 12:56:43 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41056 10 mmol/L); occurrence of maternal hypoglycaemia (BGL < 3.8 mmol/l) and incidence of neonatal hypoglycaemia (BGL ≤ 2.5 mmol/L). Analysis was stratified by diabetes type. Results: Overall, Pregnancy-IVI achieved a higher proportion of on-IVI time-in-range (70%, IQR 56-78%) compared to Adult-IVI (52%, IQR 41-69%, p < 0.0001). The duration of critical hyperglycaemia with Pregnancy-IVI was also reduced (2% [IQR 0-7] vs 8% [IQR 4-17], p < 0.0001), without an increase in hypoglycaemia. Glycaemic variability was significantly reduced with Pregnancy-IVI. No difference in the rate of neonatal hypoglycaemia was observed. The Pregnancy-IVI was most effective in women with Type 1 diabetes. Conclusion: The Pregnancy-IVI algorithm is safe and effective when used following betamethasone in type 1 diabetes in pregnancy. Further study of women with type 2 diabetes is required.]]> Wed 22 Nov 2023 16:02:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30982 Wed 19 Jan 2022 15:18:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37859 P = 0.04). The surrounding or invasion of nerves by cancer cells (perineural invasion) was detected in 12% of esophageal cancers and was associated with reduced survival (P = 0.04). Nerves were found to express the following receptors for nerve growth factor (NGF): neurotrophic receptor tyrosine kinase 1 and nerve growth factor receptor. An association was suggested between high production of NGF by cancer cells and the presence of nerves (P = 0.02). In vitro, NGF production in esophageal cancer cells was shown by Western blot, and esophageal cancer cells were able to induce neurite outgrowth in the PC12 neuronal cells. The neurotrophic activity of esophageal cancer cells was inhibited by anti-NGF blocking antibodies. Together, these data suggest that innervation is a feature in esophageal cancers that may be driven by cancer cell-released NGF.]]> Wed 17 Nov 2021 16:31:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50277 90% of clinicians would continue specialist follow-up for at least 5 years. The majority of clinicians felt that patients experienced disproportionate fear of recurrence and were reassured by follow-up. After multivariable analysis, clinicians who participated in multidisciplinary teams (MDTs) were more likely to choose de-escalated care for both initial treatment (p = .005) and follow-up care (>5 years, p = .05). Conclusion: Clinician attitudes captured by this survey reflect recent changes in guidelines towards hemithyroidectomy for low-risk WDTC, particularly amongst MDT attendees. There is a need to further examine the impact of de-escalated care on fear of recurrence and quality of life in thyroid cancer survivors.]]> Wed 12 Jul 2023 16:24:11 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53681 Wed 10 Jan 2024 10:20:43 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36867 NTR, and the proneurotrophin receptor sortilin were analyzed with immunohistochemistry in a cohort of thyroid cancers (n = 128) and compared with adenomas and normal thyroid tissues (n = 62). TrkA was detected in 20% of thyroid cancers, compared with none of the benign samples (P = 0.0007). TrkA expression was independent of histologic subtypes but associated with lymph node metastasis (P = 0.0148), suggesting the involvement of TrkA in tumor invasiveness. Nerves in the tumor microenvironment were positive for TrkA. p75^NTR was overexpressed in anaplastic thyroid cancers compared with papillary and follicular subtypes (P < 0.0001). Sortilin was overexpressed in thyroid cancers compared with benign thyroid tissues (P < 0.0001). Neurotrophin receptor expression was confirmed in a panel of thyroid cancer cell lines at the mRNA and protein levels. Functional investigations using the anaplastic thyroid cancer cell line CAL-62 found that siRNA against TrkA, p75^NTR, and sortilin decreased cell survival and cell migration through decreased SRC and ERK activation. Together, these data reveal TrkA, p75^NTR, and sortilin as potential therapeutic targets in thyroid cancer.]]> Wed 09 Feb 2022 15:52:42 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35891 3 months attending diabetes centres in Newcastle, Australia. Rates of overweight and obesity were compared with matched population survey results. Results: Data from 308 youth and 283 young adults were included. In girls, significantly higher prevalence of overweight and obesity were seen in the 5–8 (43% vs. 18%), 13–16 (41% vs. 27%), 18–24 (46% vs. 34%) and 25–30 (60% vs. 43%) years age groups; whereas in boys increased prevalence was observed in the 5–8 years age group only (41% vs. 18%). Rates of overweight and obesity increased with age across sexes. In youth, BMI standard deviation score was correlated with socio‐economic status, insulin regimen, blood pressure and blood lipids (P < 0.05). In adults, BMI was positively associated with blood pressure, and longer diabetes duration (P < 0.02). Conclusions: Overweight and obesity are over‐represented in young persons with type 1 diabetes, particularly girls. As overweight is associated with other cardiovascular disease markers early intervention is paramount.]]> Wed 06 Apr 2022 13:57:00 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36640 Tue 25 Oct 2022 09:27:51 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36646 Tue 23 Jun 2020 09:22:45 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50131 90%. Conclusion: Simple image analysis based on colour filtration/cluster analysis does not accurately identify immunohistochemically labelled nerves in thyroid cancers. Addition of deep-learning improves sensitivity with acceptable specificity, and significantly increases the number of true positive nerves detected compared to manual counting. However, the current deep learning model lacks specificity in the setting of non-specific immunostaining, which is a basis for improving further iterations of this model to facilitate study of the significance of innervation of thyroid and other cancers.]]> Tue 04 Jul 2023 12:10:29 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37622 NTR and the proneurotrophin co-receptor sortilin, remains unclear. In the present study, analysis of these proteins was conducted by immunohistochemistry and digital quantification in a series of 204 lung cancers of different histological subtypes versus 121 normal lung tissues. TrkA immunoreactivity was increased in squamous cell carcinoma compared with benign and other malignant lung cancer histological subtypes (p < 0.0001). NGF and proNGF were also increased in squamous cell carcinoma, as well as in adenocarcinoma (p < 0.0001). In contrast, p75^NTR was increased across all lung cancer histological subtypes compared to normal lung (p < 0.0001). Sortilin was higher in adenocarcinoma and small cell carcinoma (p < 0.0001). Nerves in the tumor microenvironment were negative for TrkA, NGF, proNGF, p75^NTR and sortilin. In conclusion, these data suggest a preferential therapeutic value of targeting the NGF-TrkA axis in squamous cell carcinomas of the lung.]]> Thu 24 Mar 2022 11:36:54 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41003 Thu 21 Jul 2022 10:51:13 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32094 Thu 17 Mar 2022 14:40:51 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37018 Thu 06 Aug 2020 15:46:45 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34937 10 mmol/l), occurrence of maternal hypoglycaemia (BGL < 3.8 mmol/l), and incidence of neonatal hypoglycaemia (BGL ≤ 2.5 mmol/l) if betamethasone was administered within 48 h of birth. Results: The cohorts comprised 151 women (Adult‐IVI n = 86; Pregnancy‐IVI n = 65). The primary outcome was 68% time‐at‐target [95% confidence interval (CI) 64–71%) for Pregnancy‐IVI compared with 55% (95% CI 50–60%) for Adult‐IVI (P = 0.0002). Critical maternal hyperglycaemia (0% vs. 2%, P = 0.02) and hypoglycaemia (2% vs. 12%, P = 0.02) were both lower with Pregnancy‐IVI than Adult‐IVI. Neonatal hypoglycaemia was less common after Pregnancy‐IVI (29%) than after Adult‐IVI (54%, P = 0.03). A multiple logistic regression model adjusting for potential confounders gave an odds ratio for neonatal hypoglycaemia with Pregnancy‐IVI of 0.27 (95% CI 0.10–0.76, P = 0.01). Conclusions: An IVI protocol designed for pregnancy effectively controlled maternal hyperglycaemia following betamethasone administration in GDM. This is the first intervention to show a reduction in betamethasone‐associated neonatal hypoglycaemia, linked with optimum maternal glycaemic control.]]> Thu 04 Nov 2021 10:39:22 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42698 Thu 01 Sep 2022 09:34:25 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50795 Sat 05 Aug 2023 13:56:55 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43596 Mon 26 Sep 2022 14:44:43 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48215 Mon 08 May 2023 14:47:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50755 Mon 07 Aug 2023 15:25:43 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53548 Mon 04 Dec 2023 16:08:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36624 Fri 21 Oct 2022 12:10:07 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37092 Fri 14 Aug 2020 15:16:50 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49808 Fri 02 Jun 2023 16:54:21 AEST ]]>